Description
FK 888 is a potent and selective tachykinin NK1 receptor antagonist (Ki = 0.69 nM) with 320-fold selectivity for human over rat NK1 receptors. It inhibits substance P-induced contraction of isolated guinea pig trachea (IC50 = 32 nM) and inhibits substance P-induced airway constriction in vivo following i.v. and oral administration